A well-funded research laboratory at the Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine is seeking a talented and motivated Postdoctoral Associate to participate in the exciting and innovative translational research project. The project aims to develop next-generation technology of ligandomics for drug target discovery. Ligandomics is a new technology invented by the our group to globally map disease-selective cellular ligands. Compared to transcriptomics and proteomics, ligandomics has the following advantages for drug target discovery: i) global mapping of cellular ligands with high intrinsic therapeutic potential; ii) profiling of protein function instead of expression; and iii) providing binding selectivity as a quantitative functional criterion for target selection. This project is to improve ligandomics technology and will apply ligandomics profiling to different disease models, followed by binding and functional validation of identified targets. Research activities include conducting experiments in molecular biology, protein biochemistry, cell biology, immunohistochemistry, and animal research with different disease models. Our recent publications can be found in PubMed at http://www.ncbi.nlm.nih.gov/sites/myncbi/wei.li.2/bibliography/40172985/public/?sort=date&direction=descending.
We are passionate about mentoring and fostering talented young scholars to develop successful and fruitful careers. Whether your career goals are in academia or industry, we will support you through close collaboration with the mentor or lab members to ensure that you can obtain technical skills, knowledge, and accomplishments that position you well for your future goals. The candidates will have the opportunity to learn all the cutting-edge molecular techniques, including ligandomics screening, therapeutic target validation, and drug design, as well as surgical and non-surgical methods to establish mouse models of ocular vascular diseases. In addition, the candidates will participate in manuscript preparation to publish papers in high-impact journals, attend and present at national/international meetings, and engage in grant writing to apply for the postdoctoral fellowship/young investigator grants.
If interested, please send a CV, a 1-2 page summary/Cover letter describing past accomplishments, and three references, including contact information, to Dr. Wei Li at firstname.lastname@example.org. Salary is based on NIH recommendation. Positions are available immediately.Job Duties
- Laboratory research to investigate disease mechanisms, etc.
- Animal-related research, etc.
- Organize lab, review inventory and order supplies.
- Investigates disease-specific mechanisms that contribute to pathogenesis of ocular vascular diseases and cancer/
- Characterizes disease-specific regulatory molecules in cell culture and animals.
- Characterizes different ligands that regulate diseased but not healthy vasculatures.
- Identifies disease-specific receptors that contribute to the pathogenesis in diseased but not healthy vessels.
- Develops novel ligand-guided disease-targeted therapies; and 6) to characterize these novel therapies in cell cultures and animal models.
- Analyzes research data.
- Drafts manuscript.
- Writes postdoctoral fellowship.
- MD or Ph.D. in Basic Science, Health Science, or a related field.
- No experience required.
- This position requires the candidate to perform a number of delicate procedures, including:
- molecular biology,
- cell biology,
- protein biochemistry,
- animal studies.
Baylor College of Medicine requires employees to be fully vaccinated -subject to approved exemptions-against vaccine-preventable diseases including, but not limited to, COVID-19 and influenza.
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.
PD; CA; CH; SN
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