The Baloh Laboratory Neurodegeneration Research Program is a growing and dynamic research group focused on understanding the mechanisms of degenerative diseases of the neuromuscular system with particular focus on Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's disease) and Charcot-Marie-Tooth disease (CMT). We use both cell and animal-based model systems to study disease processes and to test novel intervention strategies to develop treatments for patients. Current projects include identifying novel genetic factors influencing motor neuron survival, characterizing mouse models of ALS and CMT developed by our laboratory, and using patient derived stem cells to model ALS and CMT in a tissue culture dish. We function in a highly collaborative environment at the Regenerative Medicine Institute Brain Program, working closely with the Svendsen group and others.
The Research Associate II will help us achieve our research goals by performing and managing histology projects in the lab. The primary focus will be fixed and frozen mouse and rat tissues, but human tissues and cells may also be used. Core duties include: processing, embedding, and sectioning paraffin-embedded tissues; embedding and sectioning cryo-preserved and fresh-frozen tissues; and organizing and cataloging tissue and slide databases. Therefore, experience with routine histological techniques, with emphasis in tissue sectioning and organization is essential.
Other duties will include general tissue processer, embedder, microtome, and cryostat maintenance. Experience with histological staining, immunocytochemistry, and microscopy is a plus but not required.
The candidate will be expected to function efficiently as an individual and cooperatively with a team of faculty, research scientists, technicians and graduate students. Excellent written and oral communication and coordination of experiments and preparation of data for publication will be expected.
Participation in laboratory meetings, keeping laboratory notebooks, performing calculations, tabulating data, summarizing methods and results of related experiments will be required. In addition, the position will be responsible to keep track of their own supplies, prepare chemical solutions, maintain general lab cleanliness, and perform other work-related duties as assigned.
Goals and Worker Activities: A.75% Research related duties a.Prepare, process, embed, and section fixed, paraffin embedded tissues b.Prepare, embed, and section cryo-preserved and fresh-frozen tissues c.Maintain tissue and slide databases
B.25% General lab maintenance a.General histological equipment maintenance b.Prepare chemical solutions and maintain histology supplies c.Other duties as assigned Educational Requirements:
- Minimum of a Bachelor of Science or Bachelor of Arts degree in biological science or a related field
- Minimum of two (2) years of laboratory experience
- Understanding of general research objectives
- Familiar with routine laboratory procedures, experimental protocols, and overall lab organization
- Highly motivated and able to work independently and in a group
- Superior interpersonal, communication & organization skills, attention to detail, the ability to work across company disciplines & functional units, and be able to simultaneously manage multiple projects
- Computer skills including, but not limited to, Excel, PowerPoint, and Word
- Experience with tissue processing and sectioning required
- Familiarity with histological staining, immunohistochemistry, and microscopy a plus
- The applicant should be able to work with human & rodent tissues and occasionally work with small animals (mice & rats)
- Must be flexible to work weekends or holidays if required
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