SAGE Therapeutics is searching for a creative, resourceful, integrative thinker to play an important role in our Medicinal Chemistry programs focusing on small molecule drug discovery. A demonstrated ability to thrive in a dynamic, fast-paced, start-up matrix environment will be essential as well as strong organization skills in an outsourced setting. A strong track record in drug discovery and synthetic chemistry is essential. The role requires an individual with a proven track record of delivering quality development candidates and knowledge of the interdisciplinary drug discovery process from lead generation to development candidate nomination. Additionally, the candidate will have demonstrated excellent organizational, problem-solving and decision-making skills.
Roles and Responsibilities
Demonstrate scientific leadership in an outsourced Medicinal Chemistry environment; implement and execute medicinal chemistry strategies at various CROs
Provide oversight in synthetic chemistry including compound design and troubleshooting for synthetic challenges
Carry out in-depth analysis of complex and multi-faceted biological data (activity, selectivity, DMPK physicochemical properties etc.)
Provide timely and well-organized reports to project teams and management team forums
The ability to work and influence drug discovery cross-functional teams
Collaborate effectively with other departmental managers and functions.
Experience, Education and Specialized Knowledge and Skills
Must thrive working in a fast-paced, innovative environment while remaining flexible, proactive, resourceful and efficient. Excellent interpersonal skills, ability to develop important relationships with key stakeholders, ability to identify issues and raise to key stakeholders in order to develop relevant and realistic plans, programs and recommendations
Doctoral degree (PhD) or equivalent in synthetic organic chemistry or medicinal chemistry
5+ years of experience in the pharmaceutical industry, with a strong track record of scientific innovation, and delivery of clinical candidates
Experience in solving complexed synthetic chemistry and medicinal chemistry problems
Knowledge of the drug R&D processes and understanding of ADME/PK, pharmacology, CMC, formulations and computational chemistry
Great team player with demonstrated ability to work in dynamic and entrepreneurial environment
Scientific leader with effective organizational, interpersonal and communication skills
Demonstrated technical proficiency, scientific creativity, independent thought, and ability to effectively collaborate with others
Excellent written and oral communication skills are required
Ability to foster positive working relationships across the organization; in particular with functional and program leads
Attention to detail and the ability to work individually, within a multi-disciplinary team, as well as with external partners and vendors.
Embrace our core values: Put People First, Do Big, Be Accountable, Grow through Learning and Change, and Work Fun.
Excitement about the vision and mission of Sage.
All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.
EEO is the Law
EEO is the Law - Poster Supplement
We value our relationships with professional recruitment firms. To protect the interests of all parties, and given the large volume of inquiries received from third-party placement agencies, we are not able to respond to all agency inquiries. We do not accept unsolicited resumes from any source other than directly from candidates for current or future positions. Submission of unsolicited resumes in advance of a signed agreement between our company and a placement agency does not create an implied obligation and, if an unsolicited candidate represented by a placement agency is hired, we are not obligated to pay a fee. Only approved recruitment firms will be allowed to provide services to Sage Therapeutics, Inc.
Apply on company website