Scientist I, Oligonucleotide Analytics Job Listing at Kelly Services in San Diego, CA (Job ID US3604290_BH9974521)

Description

Scientist 2 – Oligonucleotide Analytics (Research & Development)

Location: La Jolla, CA (Fully Onsite)
Pay Rate: $52.26/hour (Contract, W-2)
Contract Length: 12 months 
Schedule: Full-time, 8 hours/day (preferred 9 AM – 5 PM)
Company: Johnson & Johnson

About the Role

Johnson & Johnson is seeking a highly motivated Scientist 2 – Oligonucleotide Analytics to join our Research & Development team in La Jolla, CA. In this role, you will be responsible for analyzing, optimizing, and ensuring the quality of oligonucleotides (siRNA and ASO) using advanced analytical techniques. This is a hands-on laboratory role, supporting innovative gene therapy projects in neuroscience (e.g., Alzheimer's research).

Key Responsibilities

• Operate LC-MS systems to perform quality testing of oligonucleotides.

• Develop, optimize, and implement analytical methods (LC-MS, HPLC) for oligonucleotide characterization.

• Adapt testing methods for different modifications (e.g., GalNAc, cholesterol, C16).

• Establish and automate high-throughput analytical workflows to support increased lab productivity.

• Perform additional analyses using HPLC-SEC, RP-IP, ion-exchange chromatography, and UV/Vis.

• Conduct QC testing for lipid nanoparticle (LNP) formulations of mRNA.

• Support cross-functional teams by providing accurate data on integrity and concentration of samples.

• Maintain lab readiness by managing consumables and reagents.

• Present results and project updates in team and departmental meetings.

Qualifications

Education

• Ph.D. in Chemistry or related field strongly preferred, OR

• Master's degree with 5+ years of relevant experience

Experience & Skills

• 1–3 years of hands-on experience at the Scientist level (or equivalent training such as postdoc).

• Proven expertise operating LC-MS systems (Thermo LTQ or Orbitrap preferred).

• Prior experience with oligonucleotide analysis (siRNA, ASO, nucleotides/nucleosides) is required.

• Strong background in HPLC/UPLC methods and method optimization.

• Familiarity with high-throughput analytical workflows and troubleshooting.

• Excellent communication and teamwork skills; ability to thrive in a collaborative, fast-paced environment.

Why Join Us

At Johnson & Johnson, we are advancing the frontiers of gene therapy and neuroscience research. As part of our team, you will contribute to cutting-edge projects that aim to bring new hope to patients worldwide. This role offers the chance to apply your expertise in analytical chemistry and oligonucleotide sciences to meaningful, real-world therapies.

If you're passionate about analytical science and want to be part of a world-class R&D team, we'd love to hear from you!

As part of our promise to talent, Kelly supports those who work with us through a variety of benefits, perks, and work-related resources. Kelly offers eligible employees voluntary benefit plans including medical, dental, vision, telemedicine, term life, whole life, accident insurance, critical illness, a legal plan, and short-term disability. As a Kelly employee, you will have access to a retirement savings plan, service bonus and holiday pay plans (earn up to eight paid holidays per benefit year), and a transit spending account. In addition, employees are entitled to earn paid sick leave under the applicable state or local plan. Click here for more information on benefits and perks that may be available to you as a member of the Kelly Talent Community.

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About Kelly

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